Dietoterapia e suplementação vitamínica no combate a hiperhomocisteinemia

Cintia Sapucaia

Resumo


Níveis elevados de Homocisteína (Hcy) têm sido considerados como fator de risco independente para diversas doenças. Alimentação balanceada e rica em folato e vitaminas do complexo B se apresentam como forma eficaz no combate a hiperhomocisteinemia. O objetivo do trabalho foi avaliar a eficiência da dietoterapia e suplementação vitamínica na redução dos níveis homocisteicos em adultos. Foram avaliados 19 adultos com idade entre 15 e 80 anos, realizando coleta de dados antropométricos: peso, altura, circunferência da cintura (CC), Índice de Massa Corpórea (IMC) e exame bioquímico de Homocisteína pré e pós-tratamento terapêutico e suplementar vitamínico. Os valores de Hcy foram comparados através do teste t student (α = 0,05) e os dados antropométricos e de concentração da Hcy foram associados através de uma matriz de correlação. Os resultados mostraram diferença estatística significativa entre as concentrações de Hcy antes e depois do tratamento (p<0,01). No pré-tratamento, 57,89% dos pacientes se encontravam com hiperhomocisteinemia (>15 μmol/L) comparado a nenhum pós-tratamento. A redução média de Hcy, peso, circunferência da cintura foram de 27,26%, 8,26 % e 9,22%, respectivamente. Não foi verificada associação entre Hcy e os dados antropométricos. Pode-se afirmar que a terapia dietética aliada à suplementação vitamínica utilizadas influenciou decisivamente na redução dos níveis de Homocisteína.

 

ABSTRACT 

Dietotherapy and vitamin supplementation to combat hyperhomocysteinemia

High levels of homocysteine (Hcy) have been considered an independent risk factor for several diseases. Balanced diet rich in folate and B vitamins present themselves as effective in combating hyperhomocysteinemia. The aim was to evaluate the effectiveness of diet therapy and vitamin supplementation in reducing homocysteine levels in adults. It was evaluated 19 adults aged 15 to 80 years, performing anthropometric data: height, weight, waist circumference (WC), body mass index (BMI) and biochemical examination before and after the therapeutic and supplementary treatment vitamin. Homocysteine values were compared using the t test student (α = 0.05) and anthropometric data and concentration of Hcy are associated through a correlation matrix. The results showed a statistically significant difference between Hcy concentrations before and after treatment (p <0.01). In the pre-treatment, 57.89% of the patients were with hyperhomocysteinemia (>15 µmol /L) compared to the no post-treatment. The average reduction of Hcy, weight, waist circumference was 27.26%, 8.26% and 9.22%, respectively. There was no association between Hcy and anthropometric data. It can be said that dietary therapy combined with vitamin supplementation used a decisive influence in reducing homocysteine levels.

Palavras-chave


Dieta; Vitaminas do complexo B; Homocisteína

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Referências


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