Diabetes Mellitus tipo 3 e exercício físico: relações entre obesidade, resistência insulínica e distúrbios cognitivos

Letícia Andrade Cerrone, Cauê Vazquez La Scala Teixeira, Renata Astride Rebelo, Danielle Arisa Caranti, Ricardo José Gomes


Introdução e objetivo: O Diabetes Mellitus tipo 3 (DM3) é um termo recentemente proposto para se referir à relação entre obesidade, resistência insulínica, diabetes mellitus tipo 2 e distúrbios cognitivos. O estudo apresenta evidências acerca do DM3, e mostra o papel do exercício físico como tratamento não farmacológico para o DM3. Materiais eMétodos: Foi realizada uma revisão de artigos publicados entre 2000  e 2016 nas bases de dados MEDLINE e LILACS. Todas as etapas do processo de revisão foram realizadas por dois pesquisadores independentes. Resultados e discussão: Verificou-se a relação de distúrbios neurológicos e cognitivos com alterações cardiometabólicas; resistência à insulina e o processo inflamatório presente na obesidade. O exercício físico (EF) teve efeitos benéficos em diversos fatores de risco para o DM3. O termo DM3 salienta a influência de condições como obesidade, resistência à insulina e diabetes mellitus tipo 2 no desenvolvimento da doença de Alzheimer. Conclusão: O EF mostrou ser uma importante estratégia de prevenção/tratamento do DM3. São necessários mais estudos sobre as modalidades de EF visando consolidar conhecimentos para a elaboração de diretrizes na prescrição do EF no contexto do DM3.



Type 3 diabetes and physical exercise: intercourses on obesity, insulin resistance and cognitive disorders

Introduction and objective: Type 3 Diabetes Mellitus (DM3) is a term recently proposed to refer to the relationship between obesity, insulin resistance, type 2 diabetes mellitus and cognitive disorders. The study presents evidences about the DM3 and shows the role of physical exercise as a non-pharmacological treatment for DM3. Materials and Methods: It was performed a review of papers published between 2000 and 2016 from MEDLINE and LILACS databases. All stages of the review process have been conducted in two independent researchers. Results and discussion: It was observed the relationship between neurological and cognitive disorders with cardiometabolic alterations, insulin resistance and obesity related inflammatory process. Physical exercise (PE) showed beneficial effects on several risk factors for DM3. The term DM3 emphasizes the influence of conditions such as obesity, insulin resistance and type 2 diabetes mellitus on the Alzheimer's disease development. Conclusion: The PE has shown to be an important prevention/treatment strategy. Further studies are needed in PE modalities to consolidate the knowledge in the development of guidelines for PE prescription in the context of DM3.


Doença de Alzheimer; Cognição; Obesidade; Diabetes Mellitus; Exercício

Texto completo:



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