Which SNPs in the FTO gene are associated with breast cancer risk? a systematic review
Abstract
Objective: To investigate the FTO gene SNPs involved in susceptibility to breast cancer in women. Materials and Methods: The article is a systematic review of the literature, following the PICOS strategy for elaborating the research question, and the PRISMA method for selecting articles. The articles found were selected from the databases: PubMed, Science Direct, Capes and BVS, with the descriptors: Breast Cancer, FTO gene and Polymorphisms, using the Boolean operator and. Case-control studies, no publication time limit, in English, Espanhol and Portuguese, which analyzed single nucleotide polymorphisms in the female population, which characterized risk for breast cancer, were included. Results: Ten studies were selected for this review. The few studies found reveal a lack of research that addresses this topic, which is of paramount importance for public health. The SNPs of the FTO gene may cause risk of breast cancer in some populations, such as Chinese and North American women, with variants rs9939609, rs16953002, but in Brazilian women this association was not found. Furthermore, we found that the rs11075995 polymorphism is associated with a higher risk of basal subtype breast cancer. Conclusion: With this review it was possible to analyze that some variants of the FTO gene cause a higher risk of breast cancer in some populations. However, this risk appears to be more associated with ethnicity, lifestyle, physical inactivity, smoking, and the molecular subtype of breast cancer. Finally, more studies are needed to add to the results found here.
References
-Algebaly, A.S.; Suliman, R.S.; Al-Qahtani, W.S. Comprehensive study for BRCA1 and BRCA2 entire coding regions in breast cancer. Clinical and Translational Oncology. Num. 23. 2021. p. 74-81.
-Azzam, S.K.; Alsafar, H.; Sajini, A.A. FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms. International Journal of Molecular Sciences. Vol. 23. Núm. 7. 2022. p. 3800.
-Bezerra, D.A.; Linhares, J.J.; Noronha, E.C.; Tavares, K.C.S.; Antunes, A.S.L.M.; Coelho, R.F.; Marques, M.V.S.M. Association of the ABCB1 C3435T gene polymorphism (SNPs) with the response to neoadjuvant chemotherapy in women with breast cancer in northeastern Brazil. Revista de Ciências Médicas e Biológicas. Vol. 19. Núm. 2. 2020. p. 305-310.
-Cunha, P.A.; Back, L.K.C.; Sereia, A.F.R.; Kubelka, C.; Ribeiro, M.C.M.; Fernandes B.L.; Souza, I.R. Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk. Molecular biology reports. Vol. 40. 2013. p. 6657-6664.
-Cheung, M.K.; Gulati, P.; O’Rahilly, S.; Yeo, G.S.H. FTO expression is regulated by availability of essential amino acids. International journal of obesity. Vol. 37. Núm. 5. 2013. p. 744-747.
-Doaei, S.; Abdollahi, S.; Mohseni, G.K.; Gholamalizadeh, M.; Akbari, M.E.; Poorhossein, S.M.; Bagheri, S.E.; Ghafouri-Fard, S.; Tabesh, G.A.; Moslem, A.; Hasanpour, A.N.; Omidi, S.; Hekmatdoost, A.; Rajabi, A.M.; Mosavi, J.S.A.; Goodarzi, M.O. The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake. Journal of Cellular and Molecular Medicine.Vol. 26. Núm. 23. 2022. p. 5794-5806.
-Fernandes, E.M.A.; Linhares, J.J. Papel dos níveis séricos de vitamina D e da síndrome metabólica e o risco de câncer de mama. Arq. Catarin. Med. Vol. 50. Núm. 2. 2021. p.257-270.
-Fonseca, A.C.P.; Abreu, G.M.; Zembrzuski, V.M.; Campos Junior, M.; Carneiro, J.R.I.; Nogueira Neto, J.F.; Cabello, G.M.K.; Cabello, P.H. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. Vol. 12. 2019. p. 667-684.
-Garcia-Closas, M.; Couch, F.J.; Lindstrom, S.; Michailidou, K.; Schmidt, M.K.; Brook, M.N.; Orr, N.; Rhie, S.K.; Riboli, E.; Feigelson, H.S.; Le Marchand, L.; Buring, J.E.; Eccles, D.; Miron, P.; Fasching, P.A.; Brauch, H.; Chang-Claude, J.; Carpenter, J.; Godwin, A. K.; Nevanlinna, H.; Giles, G.G. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature genetics. Vol. 45. Núm. 4. 2013. p. 392-398.
-García-Solís, P.; Reyes-Bastidas, M.; Flores, K.; García, O.P.; Rosado, J.L.; Méndez-Villa, L.; Garcia, G.C.; García-Gutiérrez, D.; Kuri-García, A.; Hernández-Montiel, H.L.; Soriano-Leon, O.; Villagrán-Herrera, M.E.; Solis-Sainz, J.C. Fat mass obesity-associated (FTO)(rs9939609) and melanocortin 4 receptor (MC4R)(rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children. British Journal of Nutrition. Vol. 116. Núm. 10. 2016. p. 1834-1840. 2016.
-Hernández-Caballero, M.E.; Sierra-Ramírez, J.A. Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview. Molecular biology reports. Vol. 42. 2015. p. 699-704.
-Huang, X.; Zhao, J.; Yang, M.; Li, M.; Zheng, J. Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta‐analysis. European journal of cancer care. Vol. 26. Núm. 5. 2017. p. e12464.
-Huerta-Yépez, S.; Tirado-Rodriguez, A.B.; Hankinson, O. Role of diets rich in omega-3 and omega-6 in the development of cancer. Boletín Médico Del Hospital Infantil de México. Vol. 73. Núm. 6. 2016. p. 446-456.
-IARC. International Agency for Research Cancer. 2020. Estimated number of deaths in 2020, Word. Disponível em: https://gco.iarc.fr/today/home. Acesso em 19/09/2023.
-INCA. Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2023: incidência do Câncer no Brasil. Rio de Janeiro: INCA, 2022. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/numeros/estimativa. Acesso em 17/09/2023.
-Kaklamani, V.; Yi, N.; Sadim, M.; Siziopikou, K.; Zhang, K.; Xu, Y.; Tofilon, S.; Agarwal, S.; Pasche, B.; Mantzoros, C.; The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC medical genetics. Vol. 12. 2011. p.1-10.
-Kang, J.X.; Lui, A. The role of tissue omega-6/omega-3 fatty acid ratio in the regulation of tumor angiogenesis. Cancer and Metastasis Reviews. Vol. 32. 2023. p. 201-210.
-Kentsis, A. Why do young people get cancer? Pediatr Blood Cancer. Vol. 67. Núm. 7. 2020. p. e28335.
-Kusinska, R.; Górniak, P.; Pastorczak, A.; Fendler, W.; Potemski, P.; Mlynarski, W.; Kordek, R. Influence of genomic variation in FTO at 16q12. 2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk. Molecular biology reports. Vol. 39. 2012. p. 2915-2919.
-Lan, N.; Lu, Y.; Zhang, Y.; Pu, S.; Xi, H.; Nie, X.; Liu, J.; Yuan, W. FTO-a common genetic basis for obesity and cancer. Frontiers in genetics. Vol. 11. 2020. p. 559138.
-Lee, A.; Moon, B.I.; Kim, T.H. BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies. Ann Lab Med. Vol. 40. Núm. 2. 2020. p.114-121.
-León-Mimila, P.; Villamil-Ramírez, H.; Villalobos-Comparán, M.; Villarreal-Molina, T.; Romero-Hidalgo, S.; López-Contreras, B.; Gutiérrez-Vidal, R.; Vega-Badillo, J.; Jacobo-Albavera, L.; Posadas-Romeros, C.; Canizalez-Román, A.; Río-Navarro, B.D.; Campos-Pérez, F.; Acuña-Alonzo, V.; Aguilar-Salinas, C.; Canizales-Quinteros, S. Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PloS one. Vol. 8. Núm. 8. 2013. p. e70640.
-Mansoor, Q.; Ismail, M.; Ali, U.I.; Qader, S. Linkage disequilibrium block single-nucleotide polymorphisms in FTO alpha ketoglutarate dependent dioxygenase gene inference with breast cancer and Type II diabetes in Pakistani female population. PLoS One. Vol. 18. Núm. 7. 2023. p. e0288934.
-Mojaver, M.; Mokarian, F.; Kazemi, M.; Salehi, M. Specific TaqMan allelic discrimination assay for rs1477196 and rs9939609 single nucleotide polymorphisms of FTO gene demonstrated that there is no association between these SNPs and risk of breast cancer in Iranian women. Adv Biomed Res.Vol. 4. 2015. p. 136.
-Mozafarizadeh, M.; Parvizi, O.S.; Kordestani, Z.; Manshadi, D.H.; Faridazar, A.; Houshmand, M. Association of Obesity-Related Genetic Variants (FTO and MC4R) with Breast Cancer Risk: A Population-Based Case-Control Study in Iran. Iran J Biotechnol. Vol. 17. Núm. 4. 2019. p.e2460.
-Page, M.J.; McKenzie, J.E.; Bossuyt, P.M.; Boutron, I.; Hoffmann, T.C.; Mulrow, C.D.; Shamseer, L.; Tetzlaff, J.M.; Akl, E.A.; Brennan, S.E.; Chou, R.; Glanville, J.; Grimshaw, J.M.; Hróbjartsson, A.; Lalu, M.M.; Li, T.; Loder, E.W.; Mayo-Wilson, E.; McDonald, S.; McGuinness, L.A.; Stewart, L.A.; Thomas, J.; Tricco, A.C.; Welch, V.A.; Whiting, P.; Moher, D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International journal of surgery. Vol. 88. 2021. p.105906.
-Qureshi, A.S.; Mumtaz, A.; Shahid, S.U.; Shabana, N.A. rs3751812, a common variant in fat mass and obesity-associated (FTO) gene, is associated with serum high-and low-density lipoprotein cholesterol in Pakistani individuals. Nutrition. Vol. 39. 2017. p. 92-95.
-Rodrigues, M.L.B.; Maciel, J.F.G.; Wiezel, C.E.V.; Alcarás, I.C.D.; Pessotti, A.M.B.; Simões, A.L. Ancestralidade e estrutura genética da população brasileira. Genética na Escola. Vol.17. Núm. 2. 2022. p. 139-149.
-Yin, D.; Li, Y.; Liao, X.; Tian, D.; Xu, Y.; Zhou, C.; Liu, J.; Li, S.; Zhou, J.; Nie, Y.; Liao, H.; Peng. C. FTO: a critical role in obesity and obesity-related diseases. British Journal of Nutrition. 2023. p.1-8.
-Zeng, X.; Ban, Z.; Cao, J.; Zhang, W.; Chu, T.; Lei, D.; Du, Y. Association of FTO mutations with risk and survival of breast cancer in a Chinese population. Disease markers. Vol. 2015. 2015. p. 1-7.
-Zhang, Bo.; Li, Y.; Li, L.; Chen, M.; Zhang, C.; Zuo, X.B.; Fu-sheng, Z.; Bo, L.; Zhu, J.; Li, P.; Huang, Z.L.; Xuan, H.; Li, Wei.; Chen Z.D. Association study of susceptibility loci with specific breast cancer subtypes in Chinese women. Breast cancer research and Treatment. Vol. 146. Núm. 3. 2014. p. 503-514.
-Zhu, R.M.; Lin, W.; Zhang, W.; Ren, J.T.; Su, Y.; He, J.R.; Lin, Y.; Su, F.X.; Xie, X.M.; Tang, L.Y.; Ren, Z.F. Modification effects of genetic polymorphisms in FTO, IL-6, and HSPD1 on the associations of diabetes with breast cancer risk and survival. Plos one. Vol. 12. Núm. 6. 2017. p. e0178850.
Copyright (c) 2024 Lailton Oliveira da Silva, Marilia Marques Magalhães, Joel Correia Lima, Adriel Lucas Barbosa Lira da Silva, Victor da Silva, Louhanna Pinheiro Rodrigues Teixeira, Anderson Weiny Barbalho Silva, José Juvenal Linhares
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain the copyright and grant the journal the right of first publication, with work simultaneously licensed under the Creative Commons Attribution License BY-NC which allows the sharing of the work with acknowledgment of the authorship of the work and initial publication in this journal.
- Authors are authorized to enter into additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or book chapter), with acknowledgment of authorship and initial publication in this journal.
- Authors are allowed and encouraged to post and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this can bring about productive change as well as increase impact and impact. citation of published work (See The Effect of Free Access).
