Obesity and lung function: an analysis of 2.385 adults
Abstract
Introduction: Obesity is a world health problem, responsible for a growing number of evitable deaths in all age groups. The effects of obesity on respiratory function is not completely understood. Objective: To analyze the association between obesity and lung function in adult individuals, by identifying lung ventilation disorders through spirometry examination. Materials and Methods: Here, data of body mass index (BMI) was collected from 2385 individuals, and obesity was classified as I, II or III grade. Spirometer test was performed to identify respiratory diseases and then correlated to the obesity grade. Results: Majority of investigated population presented grade I obesity. Respiratory capacity decreased with increasing age and degree of obesity for men and women, as impairments of FVC (L), FEV1 (L), FEV1/FVC (%), FEF and PEF were found according to predicted of each patient. Thus, the Restrictive Ventilatory Disorder was prevalent with the aging process and more present with the increase in the degree of obesity. Conclusion: DVR is more prevalent with the aging process and with an increase in the degree of obesity. Spirometry demonstrates that there is impairment in respiratory function due to the accumulation of adipose tissue in the human body. It is important to analyze the spirometric tests by age range in order to identify the differences in lung volumes related to senescence in obese adult individuals, impacting the diagnosis and therapeutic approach by health professionals.
References
-Albuquerque, C.G.; Andrade, F.M.; Rocha, M.A.; Oliveira, A.F.; Ladosky, W.; Victor, E.G.; Rizzo, J.Â. Determining respiratory system resistance and reactance by impulse oscillometry in obese individuals. Journal Bras Pneumol. Vol. 41. Num. 3. 2015.
-Bates, J.H.T.; Peters, U.; Daphtary, N.; MacLean, E.S.; Hodgdon, K.; Kaminsky, D.A.; Bhatawadekar, S.; Dixon, A.E. Altered airway mechanics in the context of obesity and asthma. Journal of Applied Physiology (1985). Vol. 130. Num. 1. 2021. p. 36-47.
-Bhaskaran, K.; Santos-Silva, I.; Leon, D. A.; Douglas, I.J.; Smeeth, L. Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK. The Lancet Diabetes & Endocrinology. Vol. 6. Num. 12. 2018. p. 944-953.
-Brock, J.M.; Billeter, A.; Müller-Stich, B.P.; Herth, F. Obesity and the Lung: What We Know Today. Respiration. Vol. 99. Num. 10. 2020. p. 856-866.
-Cho, S.J.; Stout-Delgado, H.W. Aging and Lung Disease. Annual Review of Physiology. Vol. 82. Num. 1. 2020. p. 433-459.
-DeBoer, M.D.; Phillips, B.R.; Mauger, D.T.; Zein, J.; Erzurum, S.C.; Fitzpatrick, A.M.; Gaston, B.M.; Myers, R.; Ross, K.R.; Chmiel, J.; Lee, M.J.; Fahy, J.V.; Peters, M.; Ly, N.P.; Wenzel, S.E.; Fajt, M.L.; Holguin, F.; Moore, W. C.; Peters, S.P.; Meyers, D.; Bleecker, E.R.; Castro, M.; Coverstone, A.M.; Bacharier, L.B.; Jarjour, N.N.; Sorkness, R.L.; Ramratnam, S.; Irani, A.M.; Israel, E.; Levy, B.; Phipatanakul, W.; Gaffin, J.M.; Gerald Teague, W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulmonary Medicine. Vol. 18. Num. 1. 2018.
-Dixon, A.E.; Peters, U. The effect of obesity on lung function. Expert Review of Respiratory Medicine. Vol. 12. Num. 9. 2018. p. 755-767.
-Forno, E.; Han, Y.Y.; Mullen, J.; Celedón, J.C. Overweight, Obesity, and Lung Function in Children and Adults - A Meta-analysis. Journal of Allergy and Clinical Immunology: In Practice. Vol. 6. Num. 2. 2018. p. 570-581.
-Graham, B.L.; Steenbruggen, I.; Miller, M.R.; Barjaktarevic, I.Z.; Cooper, B.G.; Hall, G.L.; Hallstrand, T.S.; Kaminsky, D.A.; McCarthy, K.; McCormack, M.C.; Oropez, C.E.; Rosenfeld, M.; Stanojevic, S.; Swanney, M.P.; Thompson, B.R. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. American Journal of Respiratory and Critical Care Medicine. Vol. 200. Num. 8. 2019. p. e70-e88.
-Hegewald, M.J. Impact of obesity on pulmonary function: current understanding and knowledge gaps. Current Opinion in Pulmonary Medicine. Vol. 27. Num. 2. 2021. p. 134-140.
-Holmboe, S.A.; Jasuja, R.; Lawney, B.; Priskorn, L.; Joergensen, N.; Linneberg, A.; Jensen, T.K.; Skakkebæk, N.E.; Juul, A.; Andersson, A.M. Free testosterone and cardiometabolic parameters in men: comparison of algorithms. Endocrine Connections. Vol. 10. Num. 4. 2021. p. 471-480.
-Kalidhindi, R.S.R.; Ambhore, N.S.; Bhallamudi, S.; Loganathan, J.; Sathish, V. Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice. Frontiers in Pharmacology. Vol. 10. Num. 1. 2020.
-Kawai, T.; Autieri, M.V.; Scalia, R. Adipose tissue inflammation and metabolic dysfunction in obesity. American Journal of Physiology - Cell Physiology. Vol. 320. Num. 3. 2021. p. C375-C391.
-Langan, R.C.; Goodbred, A.J. Office Spirometry: Indications and Interpretation. American Family Physician. Vol. 102. Num. 9. 2020. p. 545-552.
-Lim, J.H.; Kang, D.; Hong, Y.S.; Kim, H.; Ryu, S.; Chang, Y.; Park, H.Y.; Cho, J. Association between reproductive lifespan and lung function among postmenopausal women. Journal of Thoracic Disease. Vol. 12. Num. 8. 2020. p. 4243-4252.
-Lindner, I.A.; Kahl, J.; Rocha, F.R. Comparação do teste de espirometria entre diferentes estados nutricionais e os valores preditos de referência: um estudo transversal em indivíduos de 7 a 14 anos numa população brasileira. Revista de Pediatria SOPERJ. Vol. 23. Num. 3. 2023. p. 1-9.
-Lopes, A.C.R.; Zavan, B.; Corrêa, Y.J.C.; Vieira, T.M.; Severs, L.J.; Oliveira, L.M.; Soncini, R. Impact of obesity and ovariectomy on respiratory function in female mice. Respiratory Physiology & Neurobiology. Vol. 294. Num. 1. 2021. p. 103775.
-Mafort, T.T. Função pulmonar na obesidade. Pulmão RJ. Vol. 27. Num. 1. 2018. p. 99-102.
-Mafort, T.T.; Rufino, R.; Costa, C.H.; Lopes, A.J. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidisciplinary Respiratory Medicine. Vol. 11. Num. 1. 2016.
-Martinez-Pitre, P.J.; Sabbula, B.R.; Cascella, M. Restrictive Lung Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023.
-Melo, L.C.; Silva, M.A.; Calles, A.C. Obesity and lung function: a systematic review. Einstein. Vol. 12. Num. 1. 2014. p. 120-125.
-Moazzami, M.; Bijeh, N.; Farahati, S. Comparing the effects of six-months aerobic training on pulmonary function tests in obese and nonobese women. Journal of Sports Medicine and Physical Fitness. Vol. 61. Num. 1. 2021. p. 96-101.
-NIH. National Institute of Health. National Heart, Lung and Blood Institute. Body Mass Index (BMI). 2022. Disponível em: https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmi_dis.htm. Acesso em: 17 out. 2022.
-Nathan, S.D.; Wanger, J.; Zibrak, J.D.; Wencel, M.L.; Burg, C.; Stauffer, J.L. Using forced vital capacity (FVC) in the clinic to monitor patients with idiopathic pulmonary fibrosis (IPF): pros and cons. Expert Review of Respiratory Medicine. Vol. 15. Num. 2. 2021. p. 175-181.
-O'Donnell, D.E.; Ciavaglia, C.E.; Neder, J. A. When obesity and chronic obstructive pulmonary disease collide: physiological and clinical consequences. Annals of the American Thoracic Society. Vol. 11. Num. 4. 2014. p. 635-644.
-Oliveira, M.F.B.; Yassuda, M.S.; Aprahamian, I.; Neri, A.L.; Guariento, M.E. Hypertension, diabetes and obesity are associated with lower cognitive performance in community-dwelling elderly: Data from the FIBRA study. Dementia & Neuropsychologia. Vol. 11. Num. 4. 2017. p. 413-419.
-Pereira, R.B.; Rivera, I.R.; Brito, Z.C.T.; Silva, M.A.M. Efeito da obesidade na fisiologia e distúrbio pulmonar antes e após a cirurgia bariátrica / Effect of obesity on lung physiology and disturbances before and after bariatric surgery. Ciência e Cuidado em Saúde. Vol. 17. Num. 1. 2018. p. 1-8.
-Peters, U.; Suratt, B.T.; Bates, J.H.T.; Dixon, A.E. Beyond BMI: Obesity and Lung Disease. Chest. Vol. 153. Num. 3. 2018. p. 702-709.
-Probst-Hensch, N.; Jeong, A.; Stolz, D.; Pons, M.; Soccal, P.M.; Bettschart, R.; Jarvis, D.; Holloway, J.W.; Kronenberg, F.; Imboden, M.; Schindler, C.; Lovison, G.F. Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective. Frontiers in Public Health. Vol. 9. Num. 1. 2021.
-Rivero-Yeverino, D. Espirometría: conceptos básicos. Rev. alerg. Méx. Vol. 66. Num. 1. 2019. p. 76-84.
-Rufino, R.; Costa, C.H.; Lopes, A.J. Valores de Referências para a Espirometria. Pulmão RJ. Vol. 27. Num. 1. 2018. p. 11-20.
-Sant'Anna, M.; Carvalhal, R.F.; Oliveira, F.D.F.B.; Zin, W.A.; Lopes, A.J.; Lugon, J.R.; Guimarães, F.S. Respiratory mechanics of patients with morbid obesity. Journal Bras Pneumol. Vol. 45. Num. 3. 2019. p. 126-132.
-Schultz, K.; D'Aquino, L.C.; Soares, M.R.; Gimenez, A.; Pereira, C.A. Lung volumes and airway resistance in patients with a possible restrictive pattern on spirometry. Journal Bras Pneumol. Vol. 42. Num. 5. 2016. p. 337-342.
-Sperandio, E.F.; Arantes, R.L.; Matheus, A. C.; Silva, R.P.; Lauria, V.T.; Romiti, M.; Gagliardi, A.R.; Dourado, V.Z. Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults. Journal Bras Pneumol. Vol. 42. Num. 1. 2016. p. 10-15.
-Sposato, B.; Scalese, M.; Milanese, M.; Scichilone, N.; Scala, R.; Perrella, A. Smoking and Obesity Increase Airway Hyperresponsiveness Risk in the Elderly. Current Aging Science. Vol. 9. Num. 3. 2016. p. 245-251.
-Triebner, K.; Matulonga, B.; Johannessen, A.; Suske, S.; Benediktsdóttir, B.; Demoly, P.; Dharmage, S.C.; Franklin, K.A.; Garcia-Aymerich, J.; Gullón Blanco, J.A.; Heinrich, J.; Holm, M.; Jarvis, D.; Jõgi, R.; Lindberg, E.; Moratalla Rovira, J. M.; Muniozguren Agirre, N.; Pin, I.; Probst-Hensch, N.; Puggini, L.; Raherison, C.; Sánchez-Ramos, J.L.; Schlunssen, V.; Sunyer, J.; Svanes, C.; Hustad, S.; Bénédicte, L.; Real, F.G. Menopause Is Associated with Accelerated Lung Function Decline. American Journal of Respiratory and Critical Care Medicine. Vol. 195. Num. 8. 2017. p. 1058-1065.
-Wang, S.; Sun, X.; Hsia, T. C.; Lin, X.; Li, M. The effects of body mass index on spirometry tests among adults in Xi'an, China. Medicine (Baltimore). Vol. 96. Num. 15. 2017. p. e6596.
-OMS. Organização Mundial de Saúde. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization Technical Report Series. Vol. 894. Num. 1. 2000.
-OMS. Organização Mundial de Saúde. Obesity and overweight. Genebra. 2021. Disponível em: https://www.who.int/news-room/factsheets/ detail/obesity-and-overweight. Acesso em: 1/10/2022.
-Zakaria, R.; Harif, N.; Al-Rahbi, B.; Aziz, C. B. A.; Ahmad, A. H. Gender Differences and Obesity Influence on Pulmonary Function Parameters. Oman Medical Journal. Vol. 34. Num. 2. 2019. p. 124-130.
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