Solicitações de frações livres de hormônios tireoidianos, espermograma e globulina ligadora de hormônios sexuais na obesidade: uma perspectiva atual à prática clí­nica

  • Heitor Oliveira Santos Universidade Federal de Uberlândia
  • Santiago Tavares Paes Faculdade do Sudeste Mineiro
Palavras-chave: Metabolismo, Tiroxina, Hormônio tireoestimulante, Espermatozóide

Resumo

Introdução: Dos diversos problemas metabólicos desencadeados pela obesidade, as alterações de hormônios tireoidianos e sexuais mostram-se importantes dentro da prevenção e terapêutica clí­nica dessa doença. Objetivo: Levantar, discutir e sintetizar a importância da solicitação da triiodotironina (T3) e tiroxina (T4) livre, do mesmo modo, a relevância do espermograma e a Gobulina Ligadora de Hormônios Sexuais (SHBG) como parâmetros bioquí­micos de avaliação e tratamento da obesidade. Métodos: Foi realizada uma revisão literária utilizando como referencial os artigos publicados entre 2000 e 2017 nas bases de dados do Pubmed. Os resultados demonstram a importância da estratificação e avaliação das funções tireoidianas através dos valores dos hormônios tiroidianos livres para melhor acurácia do aspecto metabólico prejudicado pela obesidade, bem como a necessidade e relevância clí­nica das taxas de espermograma e SHBG. Conclusão: a solicitação do T3 e T4 livre deve ser encorajada na obesidade, assim como, na medida do possí­vel, o espermograma e a SHBG. Entretanto, deve-se ponderar o lado financeiro do ambiente clí­nico e ter uma boa interpretação dos exames, por exemplo, a SHBG alterada pode exibir potencial inflamatório ou se relacionar com distúrbios hormonais.

Referências

-Abitbol, V.; Borderie, D.; Polin, V.; Maksimovic, F.; Sarfati, G.; Esch, A.; Tabouret, T.; Dhooge, M.; Dreanic, J.; Perkins, G.; Coriat, R.; Chaussade, S. Diagnosis of Iron Deficiency in Inflammatory Bowel Disease by Transferrin Receptor-Ferritin Index. Medicine. Vol. 45. Num. 26. p. e1011. 2015.

-Akmal, M.; Qadri, JQ.; Al-Waili, N.S.; Thangal, S.; Haq, A.; Saloom, K.Y. Improvement in Human Semen Quality After Oral Supplementation of Vitamin C. Journal of Medicinal Food. Vol. 9. Num. 12. p. 440-442. 2006.

-Alam, M.; Rahman, M. Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. Journal of Diabetes & Metabolic Disorders. Vol. 13. Num. 1. p. 60. 2014.

-Alevizaki, M.; Saltiki, K.; Voidonikola, P.; Mantzou, E.; Papamichael, C.; Stamatelopoulos, K. Free thyroxine is an independent predictor of subcutaneous fat in euthyroid individuals. European Journal of Endocrinology. Vol. 161. Num. 3. p. 459-465. 2009.

-Amaral, A.; Lourenço, B.; Marques, M.; Ramalho-Santos, J. Mitochondria functionality and sperm quality. Reproduction. Vol. 146. Num. 5. p. R163-R174. 2013.

-Anderson, E. R.; Shah, Y. M. Iron homeostasis in the liver. Comprehensive Physiology. Vol. 3. Num. 1. p. 315-330. 2013.

-Anty, R.; Bekri, S.; Luciani, N.; Saint-Paul, M.C.; Dahman, M.; Iannelli, A.; Amor, I.B.; Staccini-Myx, A.; Huet, P.M.; Gugenheim. J.; Sadoul, J.L.; Le Marchand-Brustel, Y.; Tran, A.; Gual P. The Inflammatory C-Reactive ProteinIs Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH. The American Journal of Gastroenterology. Vol. 101. Num. 8. p. 1824-1833. 2006.

-Aroor, A. R.; Demarco, V. G. Oxidative Stress and Obesity: The Chicken or the Egg? Diabetes. Vol. 63. Num. 7. p. 2216-2218. 2014.

-Baker, M. A.; Aitken, R. J. The importance of redox regulated pathways in sperm cell biology. Molecular and Cellular Endocrinology. Vol. 216. Num. 1-2. p. 47-54. 2004.

-Bernardi, M.; Maggioli, C.; Zaccherini, G. Human albumin in the management of complications of liver cirrhosis. Critical care (London, England). Vol. 16. Num. 2. p. 211. 2012.

-Birkebaek, N.H.; Lange, A.; Holland-Fischer, P.; Kristensen,K.; Rittig, S.; Vilstrup, H.; Handberg, A.; Gronbaek, H. Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children. European Journal of Endocrinology. Vol. 163. Num. 6. p. 895-900. 2010.

-Boonchaya-Anant P.; Laichuthai, N.; Suwannasrisuk, P.; Houngngam, N.; Udomsawaengsup, S.; Snabboon, T. Changes in Testosterone Levels and Sex Hormone-Binding Globulin Levels in Extremely Obese Men after Bariatric Surgery. International Journal of Endocrinology. Vol. 2016. p. 1-5. 2016.

-Bounart, J. C.; Brown, C. W. Mitochondrial dysfunction in obesity. Current Opinion in Endocrinology, Diabetes and Obesity. Vol. 17. Num. 5. p. 446-452. 2010.

-Brand, J. S.; Van der Schouw, Y. T. Testosterone, SHBG and cardiovascular health in postmenopausal women. International Journal of Impotence Research. Vol. 22. Num. 2. p. 91-104. 2010.

-Christe, M.; Hirzel, E.; Lindinger, A.; Kern, B.; von Flüe, M.; Peterli, R.; Peters, T.; Eberle, A.N.; Lindinger, P.W. Obesity Affects Mitochondrial Citrate Synthase in Human Omental Adipose Tissue. ISRN Obesity. Vol. 2013. p. 1-8. 2013.

-Clément K.; Viguerie, N.; Diehn, M.; Alizadeh, A. Barbe, P.; Thalamas, C.; Storey, J.D.; Brown, P.O.; Barsh, G.S.; Langin, D. In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone. Genome Research. Vol. 12. Num. 2. p. 281-291. 2002.

-Dandona, P.; Dhindsa, S. Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity. The Journal of Clinical Endocrinology and Metabolism. Vol. 96. Num. 9. p.2643-2651. 2011.

-Decherney, A. H. Hormone receptors and sexuality in the human female. Journal of Women’s Health & Gender-Based Medicine. Vol. 9. p. S9-13. 2000.

-Dhanwal, D. K. Thyroid disorders andbone mineral metabolism. Indian Journal of Endocrinology and Metabolism. Vol. 15. Num. p. S107-S112. 2011.

-Diaz-Arjonilla M.; Schwarcz; M.; Swerdloff, R.S.; Wang. C. Obesity, low testosterone levels and erectile dysfunction. International Journal of Impotence Research. Vol. 21. n. 2. p. 89-98. 2009.

-Dillmann, W. H. Cellular action of thyroid hormone on the heart. Thyroid: Official Journal of the American Thyroid Association. Vol. 12. Num. 6. p. 447-452. 2002.

-Ding, E.L.; Song, Y.; Manson, J.E.; Hunter, D.J.; Lee, C.C.; Rifai, N.; Buring, J.E.; Gaziano, J.M.; Liu, S. Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men. New England Journal of Medicine. Vol. 361. Num. 12. p. 1152-1163. 2009.

-Fernández-Alonso, A.M.; Cuadros, J.L.; Chedraui, P.; Mendoza, M.; Cuadros, A.M.; Pérez-López, F.R. Obesity is related to increased menopausal symptoms among Spanish women. Menopause International. Vol. 16. Num. 3. p. 105-110. 2010.

-Ferramosca, A.; Zara, V. Bioenergetics of Mammalian Sperm Capacitation. BioMed Research International. Vol. 2014. 2014.

-Fothergill, E.; Guo, J.; Howard, L.; Kerns, J.C.; Knuth, N.D.; Brychta, R.; Chen, K.Y.; Skarulis, M.C.; Walter, M.; Walter, P.J.; Hall, K.D. Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity. Vol. 24. Num. 8. p. 1612-1619. 2016.

-Frank, J. Origins of the obesity pandemic can be analysed. Nature. Vol. 532. Num. 7598. p. 149. 2016.

-Franken, D. R.; Oehninger, S. Semen analysis and sperm function testing. Asian journal of andrology. Vol. 14. Num. 1. p. 6-13. 2012.

-Freeman, E.W.; Sammel, M.D.; Lin, H.; Gracia, C.R. Obesity and reproductive hormone levels in the transition to menopause. Menopause. Vol. 17. Num. 4. p. 718-726. 2010.

-Furukawa, S.; Fujita, T.; Shimabukuro, M.; Iwaki, M.; Yamada, Y.; Nakajima, Y.; Nakayama, O.; Makishima, M.; Matsuda, M.; Shimomura, I. Increased oxidative stress in obesity and its impact on metabolic syndrome. The Journal of clinical investigation. Vol. 114. Num. 12. p. 1752-1761. 2004.

-Garcés, C.; Oya, I.; Lasunción, M.A.; López-Simón, L.; Cano, B.; de Oya, M. Sex hormone–binding globulin and lipid profile in pubertal children. Metabolism. Vol. 59. Num. 2. p.166-171. 2010.

-Grasa, M.D.; Gulfo, J.; Camps, N.; Alcalá, R.; Monserrat, L.; Moreno-Navarrete, J.M.; Ortega, F.J.; Esteve, M.; Remesar, X.; Fernández-López, J.A.; Fernández-Real, J.M.; Alemany, M. Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity. European Journal of Endocrinology. Vol. 176. Num. 4. p. 393-404. 2017.

-Haider, A.; Yassin, A.; Doros, G.; Saad, F. Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes. International Journal ofEndocrinology. Vol. 2014. p. 1-15. 2014.

-Harris, I.D.; Fronczak, C; Roth, L.; Meacham, R.B. Fertility and the Aging Male. Reviews in Urology. Vol. 13. Num. 4. p. e184-e190. 2011.

-Hautanen, A. Synthesisand regulation of sex hormone-binding globulin in obesity. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. Vol. 24. p. S64-70. 2000.

-Heymsfield, S. B.; Wadden, T. A. Mechanisms, Pathophysiology, and Management of Obesity. New England Journal of Medicine. Vol. 376. Num. 3. p. 254-266. 2017.

-Holdstock, C.; Lind, L.; Engstrom, B.E.; Ohrvall, M.; Sundbom, M.; Larsson, A.; Karlsson, F.A. CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects. International Journal of Obesity. Vol. 29. Num. 10. p. 1275-1280. 2005.

-Hua, X.; Sun, Y.; Zhong, Y.; Feng, W.; Huang, H.; Wang, W.; Zhang, T.; Hu, Y. Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Clinical Endocrinology. Vol. 80. Num. 6. p. 877-883. 2014.

-Iacobellis, G.; Ribaudo, M.C.; Zappaterreno, A.; Iannucci, C.V.; Leonetti, F. Relationship of thyroid functionwith body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical Endocrinology. Vol. 62. Num. 4. p. 487-491. 2005.

-James, W. P. T. WHO recognition of the global obesity epidemic. International Journal ofObesity. Vol. 32. p. S120-126. 2008.

-Jensen, M. B. Vitamin D and male reproduction. Nature Reviews Endocrinology. Vol. 10. Num. 3. p. 175-186. 2014.

-Johannsen, D.L.; Knuth, N.D.; Huizenga, R.; Rood, J.C.; Ravussin, E.; Hall, K.D. Metabolic slowing with massive weight loss despite preservation of fat-free mass. The Journal of clinical endocrinology and metabolism. Vol. 97. Num. 7. p. 2489-2496. 2012.

-Kajaia, N.; Binder, H.; Dittrich, R.; Oppelt, P.G.; Flor, B.; Cupisti, S.; Beckmann, M.W.; Mueller, A. Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. European Journal of Endocrinology. Vol. 157. Num. 4. p. 499-507. 2007.

-Kell, D. B.; Pretorius, E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. Vol. 6. Num. 4. p. 748. 2014.

-Knuth, N.D.; Johannsen, D.L.; Tamboli, R.A.; Marks-Shulman, P.A.; Huizenga, R.; Chen, K.Y.; Abumrad, N.N.; Ravussin, E.; Hall, K.D. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity. Vol. 22. Num. 12. p. 2563-2569. 2014.

-La Vignera, S.; Condorelli, R.A.; Vicari, E.; Calogero, A.E. Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters. Journal ofAndrology. Vol. 33. Num. 1. p. 53-58. 2012.

-Lammers, J.; Splingart, C.; Barrière, P.; Jean, M.; Fréour, T. Double-blind prospective study comparing two automated sperm analyzers versus manual semen assessment. Journal of assisted reproduction and genetics. Vol. 31. Num. 1. p. 35-43. 2014.

-Lazarus, J.; Brown RS.; Daumerie, C.; Hubalewska-Dydejczyk, A.; Negro, R.; Vaidya, B. European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. European ThyroidJournal. Vol. 3. Num. 2. p. 76-94. 2014.

-Le, T.N.; Nestler, J.N.; Strauss, J.F.; Wickham, E.P. Sex hormone-binding globulin and type 2 diabetes mellitus. Trends in Endocrinology & Metabolism. Vol. 23. Num. 1. p. 32-40. 2012.

-Lewis, J.G.; Borowski, K.K.; Shand, B.I.; George, P.M.; Scott, R.S. Plasma Sex Hormone-binding Globulin, Corticosteroid-binding Globulin, Cortisol, and Free Cortisol Levels in Outpatients Attending a Lipid Disorders Clinic: A Cross-sectional Study of 1137 Subjects. Hormone and Metabolic Research. Vol. 42. Num. 4. p. 274-279. 2010.

-Liu, G.; Liang, L.; Bray, G.A.; Qi, L.; Hu, F.B.; Rood, J.; Sacks, F.M.; Sun, Q. Thyroid hormones and changes in body weight and metabolic parameters in response to weight-loss diets: The Pounds Lost trial. International Journal of Obesity. 2017.

-Lizcano, F.; Guzmán, G. Estrogen Deficiency and the Origin of Obesity during Menopause. BioMed Research International. Vol. 2014. p. 1-11. 2014.

-Longcope, C.; Feldman, H.A.; McKinlay, J.B.; Araujo, A.B. Diet and sex hormone-binding globulin. The Journal ofClinical Endocrinology and Metabolism. Vol. 85. Num. 1. p. 293-296. 2000.

-Luboshitzky, R.; Zabari, Z.; Shen-Orr, Z.; Herer, P.; Lavie, P. Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men. The Journal of Clinical Endocrinology & Metabolism. Vol. 86. Num. 3. p. 1134-1139. 2001.

-Luboshitzky, R.; Lavie, L.; Shen-Orr, Z.; Herer, P. Altered Luteinizing Hormone and Testosterone Secretion in Middle-Aged Obese Men with Obstructive Sleep Apnea. Obesity Research. Vol. 13. Num. 4. p. 780-786. 2005. 55-Macdonald, A. A.; Stewart, A. W.; Farquhar, C. M. Body mass index in relation to semen quality and reproductive hormones in New Zealand men: a cross-sectional study in fertility clinics. Human Reproduction. Vol. 28.Num. 12. p. 3178-3187. 2013.

-Maggio, M.; Ceda, G.P.; Lauretani, F.; Bandinelli, S.; Corsi, A.M.; Giallauria, F.; Guralnik, J.M.; Zuliani, G.; Cattabiani, C.; Parrino, S.; Ablondi, F.; Dall'Aglio, E.; Ceresini, G.; Basaria, S.; Ferrucci, L. SHBG, sex hormones, andinflammatory markers in older women. The Journal of Clinical Endocrinology and Metabolism. Vol. 96. Num. 4. p.1053-1059. 2011.

-Marino, L.; Jornayvaz, F. R. Endocrine causes of nonalcoholic fatty liver disease. World journal of gastroenterology. Vol. 21. Num. 39. p. 11053-11076. 2015.

-May-Panloup, P.; Chrétien, M.F.; Savagner, F.; Vasseur, C.; Jean, M.; Malthièry, Y.; Reynier, P. Increased sperm mitochondrial DNA content in male infertility. Human Reproduction (Oxford, England). Vol. 18. Num. 3. p. 550-556. 2003.

-Michalaki, M.A.; Vagenakis, A.G.; Leonardou, A.S.; Argentou, M.N.; Habeos, I.G.; Makri, M.G.; Psyrogiannis, A.I.; Kalfarentzos, F.E.; Kyriazopoulou, V.E. Thyroid Function in Humans with Morbid Obesity. Thyroid. Vol. 16. Num. 1. p. 73-78. 2006.

-Müller, M.J.; Enderle, J.; Pourhassan, M.; Braun, W.; Eggeling, B.; Lagerpusch, M.; Glüer, C.C.; Kehayias, J.J.; Kiosz, D.; Bosy-Westphal, A. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. American Journal of Clinical Nutrition. Vol. 102. Num. 4. p. 807-819. 2015.

-Netto, B.D.; Bettini, S.C.; Clemente, A.P.; Ferreira, J.P.; Boritza, K.; Souza, S. de F.; Von der Heyde, M.E.; Earthman, C.P.; Dâmaso, A.R. Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity. Obesity Surgery. Vol. 25. Num. 6. p. 1010-1018. 2015.

-Ng, K.K.; Donat, R.; Chan, L.; Lalak, A.; Di Pierro, I.; Handelsman, D.J. Sperm output of older men. Human Reproduction (Oxford, England). Vol. 19. Num. 8. p. 1811-1815. 2004.

-Ng Tang Fui, M.; Prendergast, L.A.; Dupuis, P.; Raval, M.; Strauss, B.J.; Zajac, J.D.; Grossmann, M. Effects of testosterone treatment on body fat and lean mass in obese menon a hypocaloric diet: a randomised controlled trial. BMC medicine. Vol. 14. Num. 1. p. 153. 2016.

-Ortega, E.; Pannacciulli, N.; Bogardus, C.; Krakoff, J. Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. The American journal of clinical nutrition. Vol. 85. Num. 2. p. 440-445. 2007.

-Paes, S.T.; Gonçalves, C.F.; Terra, M.M.; Fontoura, T.S.; Guerra, M.O.; Peters, V.M.; Mathias, P.C.; Andreazzi, A.E. Childhood obesity: a (re) programming disease? Journal of Developmental Origins of Health and Disease. p. 1-6. 2015.

-Page-Wilson, G.; Goulart, A. C.; Rexrode.; K. M. Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women. Metabolic Syndrome and Related Disorders. Vol. 7. Num. 3. p. 249-254. 2009.

-Piomboni, P.; Focarelli, R.; Stendardi, A.; Ferramosca, A.; Zara, V. The role of mitochondria in energy production for human sperm motility. International Journal of Andrology. Vol. 35. Num. 2. p. 109-124. 2012.

-Ramalho-Santos, J.; Varum, S.; Amaral, S.; Mota, P.C.; Sousa, A.P.; Amaral, A. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Human Reproduction Update. Vol. 15. Num. 5. p. 553-572. 2009.

-Rao, S. R. Inflammatory markers and bariatric surgery: a meta-analysis. Inflammation Research. Vol. 61. Num. 8. p. 789-807. 2012.

-Reinehr, T.; Andler, W. Thyroid hormones before and after weight loss in obesity. Archives of disease in childhood. Vol. 87. Num. 4. p. 320-323 2002.

-Rexrode, K.M.; Manson, J.E.; Lee, I.M.; Ridker, P.M.; Sluss, P.M.; Cook, N.R.; Buring, J.E. Sex Hormone Levels and Risk of Cardiovascular Events in Postmenopausal Women. Circulation. Vol. 108. Num. 14. p. 1688-1693. 2003.

-Rizos, C.; Elisaf, M.; Liberopoulos, E. Effects of Thyroid Dysfunction on Lipid Profile. The Open Cardiovascular Medicine Journal. Vol. 5. p. 76-84. 2011.

-Roti, E.; Minelli, R.; Salvi, M. Thyroid hormone metabolism in obesity. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity. Vol. 24. p. S113-115. 2000.

-Saad, F.; Yassin, A.; Doros, G.; Haider, A. Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies. International journal of obesity. Vol. 40. Num. 1. p. 162-170. 2016.

-Saad, E.J.; Keenan, B.S.; Danadian, K.; Lewy, V. S.; Arslanian, S. A. Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty? The Journal of Clinical Endocrinology and Metabolism. Vol. 86. Num. 10. p. 4881-4886. 2001.

-Sá, E.Q.; Sá, F.C.; Oliveira, K.C.; Feres, F.; Verreschi, I.T. Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men. Sao Paulo medical journal. Vol. 132. Num. 2. p. 111-115. 2014.

-Salma, U.; Gill, H.K.; Keith, L.G.; Tilmon, S.; Jones, C.A.; Sobti, A.; Patel, A. Male subfertility and the role of micronutrient supplementation: clinical and economic issues. Journal of experimental & clinical assisted reproduction. Vol. 8. p. 1. 2011.

-Santos, J.; Salgado, P.; Santos, C.; Mendes, P.; Saavedra, J.; Baldaque, P.; Monteiro, L.; Costa, E. Effect of bariatric surgery on weight loss, inflammation, iron metabolism, and lipid profile. Scandinavian Journal of Surgery. Vol. 103. Num. 1. p. 21-25. 2014.

-Sermondade, N.; Faure, C.; Fezeu, L.; Shayeb, A.G.; Bonde, J.P.; Jensen, T.K.; Van Wely, M.; Cao, J.; Martini, A.C.; Eskandar, M.; Chavarro, J.E.; Koloszar, S.; Twigt, J.M.; Ramlau-Hansen, C.H.; Borges, E. Jr.; Lotti. F.; Steegers-Theunissen, R.P.; Zorn, B.; Polotsky, A.J.; La Vignera, S.; Eskenazi, B.; Tremellen, K.;Magnusdottir, E.V.; Fejes, I.; Hercberg, S.; Lévy, R.; Czernichow, S. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update. Vol. 19. Num. 3. p. 221-231. 2013.

-Shin, J. A.; Mo, E.Y.; Kim, E.S.; Moon, S.D.; Han, J.H. Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects. International journal of endocrinology. Vol. 2014. p. 104-318. 2014.

-Simó, R.; Sáez-López, C.; Barbosa-Desongles, A.; Hernández, C.; Selva, D.M. Novel insights in SHBG regulation and clinical implications. Trends in Endocrinology & Metabolism. Vol. 26. Num. 7. p. 376-383. 2015.

-Sousa, A.P.; Amaral, A.; Baptista, M.; Tavares, R.; Caballero Campo, P.; Caballero Peregrín, P.; Freitas, A.; Paiva, A.; Almeida-Santos, T.; Ramalho-Santos, J. Not all sperm are equal: functional mitochondria characterize a subpopulation of human sperm with better fertilization potential. PloS One. Vol. 6. Num. 3. p. e18112. 2011.

-Tagliaferri, M.; Berselli, M.E.; Calò, G.; Minocci, A.; Savia, G.; Petroni, M.L.; Viberti, G.C.; Liuzzi, A. Subclinical Hypothyroidism in Obese Patients: Relation to Resting Energy Expenditure, Serum Leptin, Body Composition, and Lipid Profile. Obesity Research. Vol. 9. Num. 3. p. 196-201. 2001.

-Traish, A. M. Testosterone and weight loss: the evidence. Current opinion in endocrinology, diabetes, and obesity. Vol. 21. Num. 5. p. 313-322. 2014.

-Vanarsa, K.; Ye, Y.; Han, J.; Xie, C.; Mohan, C.; Wu, T.l. Inflammation associated anemia and ferritin as disease markers in SLE. Arthritis Research& Therapy. Vol. 14. Num. 4. p. R182. 2012.

-Vasan, S. S. Semen analysis and sperm function tests: How much to test? Indian journal of urology. Vol. 27. Num. 1. p. 41-48. 2011.

-Verma, A.; Jayaraman, M.; Kumar, H.K.; Modi, K.D. Hypothyroidism and obesity. Cause or effect? Saudi medical journal. Vol. 29. Num. 8. p. 1135-1138. 2008.

-Vested, A.; Ramlau-Hansen, C.H.; Bonde, J.P.; hulstrup, A.M.; Kristensen, S.L.; Toft, G. A comparison of conventional and computer-assisted semen analysis (CRISMAS software) using samples from 166 young Danish men. Asian journal ofandrology. Vol. 13. Num. 3. p. 453-458. 2011.

-Viguerie, N.; Millet, L.; Avizou, S.; Vidal, H.;Larrouy, D.; Langin D. Regulation of human adipocyte gene expression by thyroid hormone. The Journal of Clinical Endocrinology and Metabolism. Vol. 87. Num. 2. p. 630-634. 2002.

-Vincent, H. K.; Taylor A. G. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. International Journal of Obesity. Vol. 30. Num. 3. p. 400-418. 2006.

-Wang, E.Y. Body mass index effects sperm quality: a retrospective study in Northern China. Asian Journal ofAndrology. Vol. 19. Num. 2. p. 234-237. 2017.

-Wassell, J.; Michail, M.; Soliman, N.; Wardle, P.G. The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS). Clinical Laboratory. Vol. 57. Num. 1-2. p. 95-98. 2011.

-Weinberg, M.E.; Manson, J.E.; Buring, J.E.; Cook, N.R.; Seely, E.W.; Ridker, P.M.; Rexrode, K.M. Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenopausal Women. Metabolism: clinical and experimental. Vol. 55. Num. 11. p. 1473-1480. 2006.

-Wittert, G. The relationship between sleep disorders and testosterone in men. Asian journal ofandrology. Vol. 16. Num. 2. p. 262-265. 2014.

-Yang, Y.H.; Zhao, M.J.; Zhou, S.J.; Lu, W.H.; Liang, X.W.; Xiong, C.L.; Wan, C.C.; Shang, X.J.; Gu, Y.Q. Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? Asian journal of andrology. Vol. 17. Num. 6. p. 991-995. 2015.

-Yassin, A.; Doros, G. Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss. Clinical obesity. Vol. 3. Num. 3-4. p. 73-83. 2013.

-Zheng, X.; Bi, C.; Brooks, M.; Hage, D.S. Analysis of Hormone–Protein Binding in Solution by Ultrafast Affinity Extraction: Interactions of Testosterone with Human Serum Albumin and Sex Hormone Binding Globulin. Analytical Chemistry. Vol. 87. Num. 22. p. 11187-11194. 2015.

Publicado
2018-02-05
Como Citar
Santos, H. O., & Paes, S. T. (2018). Solicitações de frações livres de hormônios tireoidianos, espermograma e globulina ligadora de hormônios sexuais na obesidade: uma perspectiva atual à prática clí­nica. RBONE - Revista Brasileira De Obesidade, Nutrição E Emagrecimento, 11(67), 630-643. Recuperado de https://www.rbone.com.br/index.php/rbone/article/view/607
Seção
Artigos Científicos - Revisão