Richieste di frazioni libere da ormoni tiroidei, analisi dello sperma e globulina legante gli ormoni sessuali nell'obesità: una prospettiva attuale sulla pratica clinica
Abstract
Introduzione: Tra i vari problemi metabolici innescati dall'obesità, i cambiamenti degli ormoni tiroidei e sessuali sono importanti nella prevenzione e nella terapia clinica di questa malattia. Obiettivo: sollevare, discutere e sintetizzare l'importanza di richiedere triiodotironina (T3) e tiroxina (T4) libere, allo stesso modo, l'importanza dell'analisi dello sperma e della gobulina legante gli ormoni sessuali (SHBG) come parametri biochimici per la valutazione e il trattamento di obesità. Metodi: è stata effettuata una revisione della letteratura utilizzando come riferimento articoli pubblicati tra il 2000 e il 2017 nei database Pubmed. I risultati dimostrano l'importanza della stratificazione e della valutazione delle funzioni tiroidee attraverso i valori degli ormoni tiroidei liberi per una migliore accuratezza dell'aspetto metabolico alterato dall'obesità, nonché la necessità e la rilevanza clinica dello spermogramma e dei tassi di SHBG. Conclusione: la richiesta di T3 e T4 libero dovrebbe essere incoraggiata nell'obesità, così come, per quanto possibile, analisi dello sperma e SHBG. Tuttavia, si dovrebbe considerare l'aspetto finanziario dell'ambiente clinico e avere una buona interpretazione dei test, ad esempio, SHBG alterato può mostrare potenziale infiammatorio o essere correlato a disturbi ormonali.
Riferimenti bibliografici
-Abitbol, V.; Borderie, D.; Polin, V.; Maksimovic, F.; Sarfati, G.; Esch, A.; Tabouret, T.; Dhooge, M.; Dreanic, J.; Perkins, G.; Coriat, R.; Chaussade, S. Diagnosis of Iron Deficiency in Inflammatory Bowel Disease by Transferrin Receptor-Ferritin Index. Medicine. Vol. 45. Num. 26. p. e1011. 2015.
-Akmal, M.; Qadri, JQ.; Al-Waili, N.S.; Thangal, S.; Haq, A.; Saloom, K.Y. Improvement in Human Semen Quality After Oral Supplementation of Vitamin C. Journal of Medicinal Food. Vol. 9. Num. 12. p. 440-442. 2006.
-Alam, M.; Rahman, M. Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. Journal of Diabetes & Metabolic Disorders. Vol. 13. Num. 1. p. 60. 2014.
-Alevizaki, M.; Saltiki, K.; Voidonikola, P.; Mantzou, E.; Papamichael, C.; Stamatelopoulos, K. Free thyroxine is an independent predictor of subcutaneous fat in euthyroid individuals. European Journal of Endocrinology. Vol. 161. Num. 3. p. 459-465. 2009.
-Amaral, A.; Lourenço, B.; Marques, M.; Ramalho-Santos, J. Mitochondria functionality and sperm quality. Reproduction. Vol. 146. Num. 5. p. R163-R174. 2013.
-Anderson, E. R.; Shah, Y. M. Iron homeostasis in the liver. Comprehensive Physiology. Vol. 3. Num. 1. p. 315-330. 2013.
-Anty, R.; Bekri, S.; Luciani, N.; Saint-Paul, M.C.; Dahman, M.; Iannelli, A.; Amor, I.B.; Staccini-Myx, A.; Huet, P.M.; Gugenheim. J.; Sadoul, J.L.; Le Marchand-Brustel, Y.; Tran, A.; Gual P. The Inflammatory C-Reactive ProteinIs Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH. The American Journal of Gastroenterology. Vol. 101. Num. 8. p. 1824-1833. 2006.
-Aroor, A. R.; Demarco, V. G. Oxidative Stress and Obesity: The Chicken or the Egg? Diabetes. Vol. 63. Num. 7. p. 2216-2218. 2014.
-Baker, M. A.; Aitken, R. J. The importance of redox regulated pathways in sperm cell biology. Molecular and Cellular Endocrinology. Vol. 216. Num. 1-2. p. 47-54. 2004.
-Bernardi, M.; Maggioli, C.; Zaccherini, G. Human albumin in the management of complications of liver cirrhosis. Critical care (London, England). Vol. 16. Num. 2. p. 211. 2012.
-Birkebaek, N.H.; Lange, A.; Holland-Fischer, P.; Kristensen,K.; Rittig, S.; Vilstrup, H.; Handberg, A.; Gronbaek, H. Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children. European Journal of Endocrinology. Vol. 163. Num. 6. p. 895-900. 2010.
-Boonchaya-Anant P.; Laichuthai, N.; Suwannasrisuk, P.; Houngngam, N.; Udomsawaengsup, S.; Snabboon, T. Changes in Testosterone Levels and Sex Hormone-Binding Globulin Levels in Extremely Obese Men after Bariatric Surgery. International Journal of Endocrinology. Vol. 2016. p. 1-5. 2016.
-Bounart, J. C.; Brown, C. W. Mitochondrial dysfunction in obesity. Current Opinion in Endocrinology, Diabetes and Obesity. Vol. 17. Num. 5. p. 446-452. 2010.
-Brand, J. S.; Van der Schouw, Y. T. Testosterone, SHBG and cardiovascular health in postmenopausal women. International Journal of Impotence Research. Vol. 22. Num. 2. p. 91-104. 2010.
-Christe, M.; Hirzel, E.; Lindinger, A.; Kern, B.; von Flüe, M.; Peterli, R.; Peters, T.; Eberle, A.N.; Lindinger, P.W. Obesity Affects Mitochondrial Citrate Synthase in Human Omental Adipose Tissue. ISRN Obesity. Vol. 2013. p. 1-8. 2013.
-Clément K.; Viguerie, N.; Diehn, M.; Alizadeh, A. Barbe, P.; Thalamas, C.; Storey, J.D.; Brown, P.O.; Barsh, G.S.; Langin, D. In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone. Genome Research. Vol. 12. Num. 2. p. 281-291. 2002.
-Dandona, P.; Dhindsa, S. Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity. The Journal of Clinical Endocrinology and Metabolism. Vol. 96. Num. 9. p.2643-2651. 2011.
-Decherney, A. H. Hormone receptors and sexuality in the human female. Journal of Women’s Health & Gender-Based Medicine. Vol. 9. p. S9-13. 2000.
-Dhanwal, D. K. Thyroid disorders andbone mineral metabolism. Indian Journal of Endocrinology and Metabolism. Vol. 15. Num. p. S107-S112. 2011.
-Diaz-Arjonilla M.; Schwarcz; M.; Swerdloff, R.S.; Wang. C. Obesity, low testosterone levels and erectile dysfunction. International Journal of Impotence Research. Vol. 21. n. 2. p. 89-98. 2009.
-Dillmann, W. H. Cellular action of thyroid hormone on the heart. Thyroid: Official Journal of the American Thyroid Association. Vol. 12. Num. 6. p. 447-452. 2002.
-Ding, E.L.; Song, Y.; Manson, J.E.; Hunter, D.J.; Lee, C.C.; Rifai, N.; Buring, J.E.; Gaziano, J.M.; Liu, S. Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men. New England Journal of Medicine. Vol. 361. Num. 12. p. 1152-1163. 2009.
-Fernández-Alonso, A.M.; Cuadros, J.L.; Chedraui, P.; Mendoza, M.; Cuadros, A.M.; Pérez-López, F.R. Obesity is related to increased menopausal symptoms among Spanish women. Menopause International. Vol. 16. Num. 3. p. 105-110. 2010.
-Ferramosca, A.; Zara, V. Bioenergetics of Mammalian Sperm Capacitation. BioMed Research International. Vol. 2014. 2014.
-Fothergill, E.; Guo, J.; Howard, L.; Kerns, J.C.; Knuth, N.D.; Brychta, R.; Chen, K.Y.; Skarulis, M.C.; Walter, M.; Walter, P.J.; Hall, K.D. Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity. Vol. 24. Num. 8. p. 1612-1619. 2016.
-Frank, J. Origins of the obesity pandemic can be analysed. Nature. Vol. 532. Num. 7598. p. 149. 2016.
-Franken, D. R.; Oehninger, S. Semen analysis and sperm function testing. Asian journal of andrology. Vol. 14. Num. 1. p. 6-13. 2012.
-Freeman, E.W.; Sammel, M.D.; Lin, H.; Gracia, C.R. Obesity and reproductive hormone levels in the transition to menopause. Menopause. Vol. 17. Num. 4. p. 718-726. 2010.
-Furukawa, S.; Fujita, T.; Shimabukuro, M.; Iwaki, M.; Yamada, Y.; Nakajima, Y.; Nakayama, O.; Makishima, M.; Matsuda, M.; Shimomura, I. Increased oxidative stress in obesity and its impact on metabolic syndrome. The Journal of clinical investigation. Vol. 114. Num. 12. p. 1752-1761. 2004.
-Garcés, C.; Oya, I.; Lasunción, M.A.; López-Simón, L.; Cano, B.; de Oya, M. Sex hormone–binding globulin and lipid profile in pubertal children. Metabolism. Vol. 59. Num. 2. p.166-171. 2010.
-Grasa, M.D.; Gulfo, J.; Camps, N.; Alcalá, R.; Monserrat, L.; Moreno-Navarrete, J.M.; Ortega, F.J.; Esteve, M.; Remesar, X.; Fernández-López, J.A.; Fernández-Real, J.M.; Alemany, M. Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity. European Journal of Endocrinology. Vol. 176. Num. 4. p. 393-404. 2017.
-Haider, A.; Yassin, A.; Doros, G.; Saad, F. Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes. International Journal ofEndocrinology. Vol. 2014. p. 1-15. 2014.
-Harris, I.D.; Fronczak, C; Roth, L.; Meacham, R.B. Fertility and the Aging Male. Reviews in Urology. Vol. 13. Num. 4. p. e184-e190. 2011.
-Hautanen, A. Synthesisand regulation of sex hormone-binding globulin in obesity. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. Vol. 24. p. S64-70. 2000.
-Heymsfield, S. B.; Wadden, T. A. Mechanisms, Pathophysiology, and Management of Obesity. New England Journal of Medicine. Vol. 376. Num. 3. p. 254-266. 2017.
-Holdstock, C.; Lind, L.; Engstrom, B.E.; Ohrvall, M.; Sundbom, M.; Larsson, A.; Karlsson, F.A. CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects. International Journal of Obesity. Vol. 29. Num. 10. p. 1275-1280. 2005.
-Hua, X.; Sun, Y.; Zhong, Y.; Feng, W.; Huang, H.; Wang, W.; Zhang, T.; Hu, Y. Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Clinical Endocrinology. Vol. 80. Num. 6. p. 877-883. 2014.
-Iacobellis, G.; Ribaudo, M.C.; Zappaterreno, A.; Iannucci, C.V.; Leonetti, F. Relationship of thyroid functionwith body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical Endocrinology. Vol. 62. Num. 4. p. 487-491. 2005.
-James, W. P. T. WHO recognition of the global obesity epidemic. International Journal ofObesity. Vol. 32. p. S120-126. 2008.
-Jensen, M. B. Vitamin D and male reproduction. Nature Reviews Endocrinology. Vol. 10. Num. 3. p. 175-186. 2014.
-Johannsen, D.L.; Knuth, N.D.; Huizenga, R.; Rood, J.C.; Ravussin, E.; Hall, K.D. Metabolic slowing with massive weight loss despite preservation of fat-free mass. The Journal of clinical endocrinology and metabolism. Vol. 97. Num. 7. p. 2489-2496. 2012.
-Kajaia, N.; Binder, H.; Dittrich, R.; Oppelt, P.G.; Flor, B.; Cupisti, S.; Beckmann, M.W.; Mueller, A. Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome. European Journal of Endocrinology. Vol. 157. Num. 4. p. 499-507. 2007.
-Kell, D. B.; Pretorius, E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. Vol. 6. Num. 4. p. 748. 2014.
-Knuth, N.D.; Johannsen, D.L.; Tamboli, R.A.; Marks-Shulman, P.A.; Huizenga, R.; Chen, K.Y.; Abumrad, N.N.; Ravussin, E.; Hall, K.D. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity. Vol. 22. Num. 12. p. 2563-2569. 2014.
-La Vignera, S.; Condorelli, R.A.; Vicari, E.; Calogero, A.E. Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters. Journal ofAndrology. Vol. 33. Num. 1. p. 53-58. 2012.
-Lammers, J.; Splingart, C.; Barrière, P.; Jean, M.; Fréour, T. Double-blind prospective study comparing two automated sperm analyzers versus manual semen assessment. Journal of assisted reproduction and genetics. Vol. 31. Num. 1. p. 35-43. 2014.
-Lazarus, J.; Brown RS.; Daumerie, C.; Hubalewska-Dydejczyk, A.; Negro, R.; Vaidya, B. European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. European ThyroidJournal. Vol. 3. Num. 2. p. 76-94. 2014.
-Le, T.N.; Nestler, J.N.; Strauss, J.F.; Wickham, E.P. Sex hormone-binding globulin and type 2 diabetes mellitus. Trends in Endocrinology & Metabolism. Vol. 23. Num. 1. p. 32-40. 2012.
-Lewis, J.G.; Borowski, K.K.; Shand, B.I.; George, P.M.; Scott, R.S. Plasma Sex Hormone-binding Globulin, Corticosteroid-binding Globulin, Cortisol, and Free Cortisol Levels in Outpatients Attending a Lipid Disorders Clinic: A Cross-sectional Study of 1137 Subjects. Hormone and Metabolic Research. Vol. 42. Num. 4. p. 274-279. 2010.
-Liu, G.; Liang, L.; Bray, G.A.; Qi, L.; Hu, F.B.; Rood, J.; Sacks, F.M.; Sun, Q. Thyroid hormones and changes in body weight and metabolic parameters in response to weight-loss diets: The Pounds Lost trial. International Journal of Obesity. 2017.
-Lizcano, F.; Guzmán, G. Estrogen Deficiency and the Origin of Obesity during Menopause. BioMed Research International. Vol. 2014. p. 1-11. 2014.
-Longcope, C.; Feldman, H.A.; McKinlay, J.B.; Araujo, A.B. Diet and sex hormone-binding globulin. The Journal ofClinical Endocrinology and Metabolism. Vol. 85. Num. 1. p. 293-296. 2000.
-Luboshitzky, R.; Zabari, Z.; Shen-Orr, Z.; Herer, P.; Lavie, P. Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men. The Journal of Clinical Endocrinology & Metabolism. Vol. 86. Num. 3. p. 1134-1139. 2001.
-Luboshitzky, R.; Lavie, L.; Shen-Orr, Z.; Herer, P. Altered Luteinizing Hormone and Testosterone Secretion in Middle-Aged Obese Men with Obstructive Sleep Apnea. Obesity Research. Vol. 13. Num. 4. p. 780-786. 2005. 55-Macdonald, A. A.; Stewart, A. W.; Farquhar, C. M. Body mass index in relation to semen quality and reproductive hormones in New Zealand men: a cross-sectional study in fertility clinics. Human Reproduction. Vol. 28.Num. 12. p. 3178-3187. 2013.
-Maggio, M.; Ceda, G.P.; Lauretani, F.; Bandinelli, S.; Corsi, A.M.; Giallauria, F.; Guralnik, J.M.; Zuliani, G.; Cattabiani, C.; Parrino, S.; Ablondi, F.; Dall'Aglio, E.; Ceresini, G.; Basaria, S.; Ferrucci, L. SHBG, sex hormones, andinflammatory markers in older women. The Journal of Clinical Endocrinology and Metabolism. Vol. 96. Num. 4. p.1053-1059. 2011.
-Marino, L.; Jornayvaz, F. R. Endocrine causes of nonalcoholic fatty liver disease. World journal of gastroenterology. Vol. 21. Num. 39. p. 11053-11076. 2015.
-May-Panloup, P.; Chrétien, M.F.; Savagner, F.; Vasseur, C.; Jean, M.; Malthièry, Y.; Reynier, P. Increased sperm mitochondrial DNA content in male infertility. Human Reproduction (Oxford, England). Vol. 18. Num. 3. p. 550-556. 2003.
-Michalaki, M.A.; Vagenakis, A.G.; Leonardou, A.S.; Argentou, M.N.; Habeos, I.G.; Makri, M.G.; Psyrogiannis, A.I.; Kalfarentzos, F.E.; Kyriazopoulou, V.E. Thyroid Function in Humans with Morbid Obesity. Thyroid. Vol. 16. Num. 1. p. 73-78. 2006.
-Müller, M.J.; Enderle, J.; Pourhassan, M.; Braun, W.; Eggeling, B.; Lagerpusch, M.; Glüer, C.C.; Kehayias, J.J.; Kiosz, D.; Bosy-Westphal, A. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. American Journal of Clinical Nutrition. Vol. 102. Num. 4. p. 807-819. 2015.
-Netto, B.D.; Bettini, S.C.; Clemente, A.P.; Ferreira, J.P.; Boritza, K.; Souza, S. de F.; Von der Heyde, M.E.; Earthman, C.P.; Dâmaso, A.R. Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity. Obesity Surgery. Vol. 25. Num. 6. p. 1010-1018. 2015.
-Ng, K.K.; Donat, R.; Chan, L.; Lalak, A.; Di Pierro, I.; Handelsman, D.J. Sperm output of older men. Human Reproduction (Oxford, England). Vol. 19. Num. 8. p. 1811-1815. 2004.
-Ng Tang Fui, M.; Prendergast, L.A.; Dupuis, P.; Raval, M.; Strauss, B.J.; Zajac, J.D.; Grossmann, M. Effects of testosterone treatment on body fat and lean mass in obese menon a hypocaloric diet: a randomised controlled trial. BMC medicine. Vol. 14. Num. 1. p. 153. 2016.
-Ortega, E.; Pannacciulli, N.; Bogardus, C.; Krakoff, J. Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. The American journal of clinical nutrition. Vol. 85. Num. 2. p. 440-445. 2007.
-Paes, S.T.; Gonçalves, C.F.; Terra, M.M.; Fontoura, T.S.; Guerra, M.O.; Peters, V.M.; Mathias, P.C.; Andreazzi, A.E. Childhood obesity: a (re) programming disease? Journal of Developmental Origins of Health and Disease. p. 1-6. 2015.
-Page-Wilson, G.; Goulart, A. C.; Rexrode.; K. M. Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women. Metabolic Syndrome and Related Disorders. Vol. 7. Num. 3. p. 249-254. 2009.
-Piomboni, P.; Focarelli, R.; Stendardi, A.; Ferramosca, A.; Zara, V. The role of mitochondria in energy production for human sperm motility. International Journal of Andrology. Vol. 35. Num. 2. p. 109-124. 2012.
-Ramalho-Santos, J.; Varum, S.; Amaral, S.; Mota, P.C.; Sousa, A.P.; Amaral, A. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Human Reproduction Update. Vol. 15. Num. 5. p. 553-572. 2009.
-Rao, S. R. Inflammatory markers and bariatric surgery: a meta-analysis. Inflammation Research. Vol. 61. Num. 8. p. 789-807. 2012.
-Reinehr, T.; Andler, W. Thyroid hormones before and after weight loss in obesity. Archives of disease in childhood. Vol. 87. Num. 4. p. 320-323 2002.
-Rexrode, K.M.; Manson, J.E.; Lee, I.M.; Ridker, P.M.; Sluss, P.M.; Cook, N.R.; Buring, J.E. Sex Hormone Levels and Risk of Cardiovascular Events in Postmenopausal Women. Circulation. Vol. 108. Num. 14. p. 1688-1693. 2003.
-Rizos, C.; Elisaf, M.; Liberopoulos, E. Effects of Thyroid Dysfunction on Lipid Profile. The Open Cardiovascular Medicine Journal. Vol. 5. p. 76-84. 2011.
-Roti, E.; Minelli, R.; Salvi, M. Thyroid hormone metabolism in obesity. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity. Vol. 24. p. S113-115. 2000.
-Saad, F.; Yassin, A.; Doros, G.; Haider, A. Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies. International journal of obesity. Vol. 40. Num. 1. p. 162-170. 2016.
-Saad, E.J.; Keenan, B.S.; Danadian, K.; Lewy, V. S.; Arslanian, S. A. Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty? The Journal of Clinical Endocrinology and Metabolism. Vol. 86. Num. 10. p. 4881-4886. 2001.
-Sá, E.Q.; Sá, F.C.; Oliveira, K.C.; Feres, F.; Verreschi, I.T. Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men. Sao Paulo medical journal. Vol. 132. Num. 2. p. 111-115. 2014.
-Salma, U.; Gill, H.K.; Keith, L.G.; Tilmon, S.; Jones, C.A.; Sobti, A.; Patel, A. Male subfertility and the role of micronutrient supplementation: clinical and economic issues. Journal of experimental & clinical assisted reproduction. Vol. 8. p. 1. 2011.
-Santos, J.; Salgado, P.; Santos, C.; Mendes, P.; Saavedra, J.; Baldaque, P.; Monteiro, L.; Costa, E. Effect of bariatric surgery on weight loss, inflammation, iron metabolism, and lipid profile. Scandinavian Journal of Surgery. Vol. 103. Num. 1. p. 21-25. 2014.
-Sermondade, N.; Faure, C.; Fezeu, L.; Shayeb, A.G.; Bonde, J.P.; Jensen, T.K.; Van Wely, M.; Cao, J.; Martini, A.C.; Eskandar, M.; Chavarro, J.E.; Koloszar, S.; Twigt, J.M.; Ramlau-Hansen, C.H.; Borges, E. Jr.; Lotti. F.; Steegers-Theunissen, R.P.; Zorn, B.; Polotsky, A.J.; La Vignera, S.; Eskenazi, B.; Tremellen, K.;Magnusdottir, E.V.; Fejes, I.; Hercberg, S.; Lévy, R.; Czernichow, S. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update. Vol. 19. Num. 3. p. 221-231. 2013.
-Shin, J. A.; Mo, E.Y.; Kim, E.S.; Moon, S.D.; Han, J.H. Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects. International journal of endocrinology. Vol. 2014. p. 104-318. 2014.
-Simó, R.; Sáez-López, C.; Barbosa-Desongles, A.; Hernández, C.; Selva, D.M. Novel insights in SHBG regulation and clinical implications. Trends in Endocrinology & Metabolism. Vol. 26. Num. 7. p. 376-383. 2015.
-Sousa, A.P.; Amaral, A.; Baptista, M.; Tavares, R.; Caballero Campo, P.; Caballero Peregrín, P.; Freitas, A.; Paiva, A.; Almeida-Santos, T.; Ramalho-Santos, J. Not all sperm are equal: functional mitochondria characterize a subpopulation of human sperm with better fertilization potential. PloS One. Vol. 6. Num. 3. p. e18112. 2011.
-Tagliaferri, M.; Berselli, M.E.; Calò, G.; Minocci, A.; Savia, G.; Petroni, M.L.; Viberti, G.C.; Liuzzi, A. Subclinical Hypothyroidism in Obese Patients: Relation to Resting Energy Expenditure, Serum Leptin, Body Composition, and Lipid Profile. Obesity Research. Vol. 9. Num. 3. p. 196-201. 2001.
-Traish, A. M. Testosterone and weight loss: the evidence. Current opinion in endocrinology, diabetes, and obesity. Vol. 21. Num. 5. p. 313-322. 2014.
-Vanarsa, K.; Ye, Y.; Han, J.; Xie, C.; Mohan, C.; Wu, T.l. Inflammation associated anemia and ferritin as disease markers in SLE. Arthritis Research& Therapy. Vol. 14. Num. 4. p. R182. 2012.
-Vasan, S. S. Semen analysis and sperm function tests: How much to test? Indian journal of urology. Vol. 27. Num. 1. p. 41-48. 2011.
-Verma, A.; Jayaraman, M.; Kumar, H.K.; Modi, K.D. Hypothyroidism and obesity. Cause or effect? Saudi medical journal. Vol. 29. Num. 8. p. 1135-1138. 2008.
-Vested, A.; Ramlau-Hansen, C.H.; Bonde, J.P.; hulstrup, A.M.; Kristensen, S.L.; Toft, G. A comparison of conventional and computer-assisted semen analysis (CRISMAS software) using samples from 166 young Danish men. Asian journal ofandrology. Vol. 13. Num. 3. p. 453-458. 2011.
-Viguerie, N.; Millet, L.; Avizou, S.; Vidal, H.;Larrouy, D.; Langin D. Regulation of human adipocyte gene expression by thyroid hormone. The Journal of Clinical Endocrinology and Metabolism. Vol. 87. Num. 2. p. 630-634. 2002.
-Vincent, H. K.; Taylor A. G. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. International Journal of Obesity. Vol. 30. Num. 3. p. 400-418. 2006.
-Wang, E.Y. Body mass index effects sperm quality: a retrospective study in Northern China. Asian Journal ofAndrology. Vol. 19. Num. 2. p. 234-237. 2017.
-Wassell, J.; Michail, M.; Soliman, N.; Wardle, P.G. The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS). Clinical Laboratory. Vol. 57. Num. 1-2. p. 95-98. 2011.
-Weinberg, M.E.; Manson, J.E.; Buring, J.E.; Cook, N.R.; Seely, E.W.; Ridker, P.M.; Rexrode, K.M. Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenopausal Women. Metabolism: clinical and experimental. Vol. 55. Num. 11. p. 1473-1480. 2006.
-Wittert, G. The relationship between sleep disorders and testosterone in men. Asian journal ofandrology. Vol. 16. Num. 2. p. 262-265. 2014.
-Yang, Y.H.; Zhao, M.J.; Zhou, S.J.; Lu, W.H.; Liang, X.W.; Xiong, C.L.; Wan, C.C.; Shang, X.J.; Gu, Y.Q. Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? Asian journal of andrology. Vol. 17. Num. 6. p. 991-995. 2015.
-Yassin, A.; Doros, G. Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss. Clinical obesity. Vol. 3. Num. 3-4. p. 73-83. 2013.
-Zheng, X.; Bi, C.; Brooks, M.; Hage, D.S. Analysis of Hormone–Protein Binding in Solution by Ultrafast Affinity Extraction: Interactions of Testosterone with Human Serum Albumin and Sex Hormone Binding Globulin. Analytical Chemistry. Vol. 87. Num. 22. p. 11187-11194. 2015.
Gli autori che pubblicano in questa rivista accettano i seguenti termini:
Gli autori mantengono i diritti d'autore e concedono alla rivista il diritto di prima pubblicazione, con l'opera contemporaneamente concessa in licenza con una licenza di attribuzione Creative Commons BY-NC che consente la condivisione dell'opera con riconoscimento della paternità dell'opera e pubblicazione iniziale in questa rivista.
Gli autori sono autorizzati ad assumere ulteriori contratti separatamente, per la distribuzione non esclusiva della versione dell'opera pubblicata su questa rivista (es. da pubblicare in un repository istituzionale o come capitolo di libro), con riconoscimento della paternità e pubblicazione iniziale in questa rivista .
Gli autori sono autorizzati e incoraggiati a pubblicare e distribuire il loro lavoro online (ad es. in archivi istituzionali o sulla loro pagina personale) in qualsiasi momento prima o durante il processo editoriale, poiché ciò può generare cambiamenti produttivi, nonché aumentare l'impatto e la citazione del pubblicato lavoro (Vedi L'effetto dell'accesso aperto).
