Positive and negative predictors for body mass in adolescents who underwent bariatric and metabolic surgery
Abstract
Obesity is a chronic multifactorial disease whose clinical symptoms are related to several comorbidities. These are usually identified by measuring the patient’s Body Mass Index. In severe cases, bariatric surgery is an effective method of controlling weight and improving the patient’s metabolic profile, although the maintenance of these results depends on continuous medical monitoring. The purpose of this study was to evaluate the predictors of weight loss in adolescents who underwent bariatric surgery and were treated at the Gastro Obeso Center, in São Paulo, between 2008 and 2024, with the participation of 40 patients, the majority of whom were female (65%). They were evaluated by anthropometric and biochemical exams and the applied statistical analysis consisted of parametric and nonparametric tests, ANOVA of the repeated measurements, and multiple linear regression models. A varied weight loss was observed 12 months after the surgery, especially in the women: the average was reduced to 79,4 kg and the Body Mass Index was from 45,5 kg/m2 to 28,0 kg/m2. The metabolic parameters also improved, with a decrease in insulin resistance indicated by HOMA-IR. The main predictors of weight loss were the female gender, an initially larger body mass, and lower levels in the HOMA-IR. In contrast, the male gender and older age were associated with lower weight loss. Thus, this study reiterated the need to analyze the predictors, to optimize surgical results and improve the quality of life of these patients.
References
-Al-Khyatt, W.; Ryall, R.; Leeder, P.; Ahmed, J.; Awad, S. Predictors of Inadequate Weight Loss After Laparoscopic Gastric Bypass for Morbid Obesity. Obesity Surgery. Vol. 27. Num. 6. 2017. p. 1446-1452.
-Andersson, D.P.; Dahlman, I.; Hogling, D.E.; Bäckdahl, J.; Toft, E.; Qvisth, V.; Näslund, E.; Thorell, A.; Rydén, M.; Arner, P. Improved Metabolism and Body Composition Beyond Normal Levels Following Gastric Bypass Surgery: A Longitudinal Study. Journal of Internal Medicine. Vol. 285. Num. 1. 2019. p. 92-101.
-Armstrong, S.; Wong, C.A.; Perrin, E.; Page, S.; Sibley, L.; Skinner, A. Association of Physical Activity with Income, Race/Ethnicity, and Sex Among Adolescents and Young Adults in the United States: Findings from the National Health and Nutrition Examination Survey, 2007-2016. JAMA Pediatrics. Vol. 172. Num. 8. 2018. p. 732-740.
-Barros, L.M.; Frota, N.M.; Moreira, R.A.; Araújo, T.M.; Caetano, J.A. Assessment of Bariatric Surgery Results. Revista Gaúcha de Enfermagem. Vol. 36. Num. 1. 2015. p. 21-27.
-Bonn, S.E.; Christenson, A.; Eke, H.; Sjöblom, L.; Dahlgren, A.; Trolle Lagerros, Y. Does Eating Behavior Among Adolescentes and Young Adults Seeking Obesity Treatment Differ Depending on Sex, Body Composition, and Parental Contry of Birth? BMC Public Heath. Vol. 22. Num. 1. 2022. p. 1895.
-Braga, J.G.R.; Ramos, A.C.; Callejas-Neto, F.; Chaim, E.A.; Cazzo, E. Weight Loss and Quality of Life After One Anastomosis Gastric Bypass: A 2-Year Follow-Up Study. Arquivos de Gastroenterologia. Vol. 60. Num. 2. 2023. p. 241-246.
-Castanha, C.R.; Ferraz, A.A.B.; Castanha, A.R.; Belo, G.Q.M.B.; Lacerda, R.M.R.; Vilar, L. Avaliação da qualidade de vida, perda de peso e comorbidades de pacientes submetidos à cirurgia bariátrica. Revista do Colégio Brasileiro de Cirurgiões. Vol. 45. Num. 3. 2018. e1864.
-Cimpean, S.; Raglione, D.; Cadiere, B.; Cadiere, G.B.; Byabene, G.D. The Place Bariatric Surgery and Multidisciplinary Team in the Treatment of Obesity in Adolescent Patients. Archives of Surgery and Clinical Case Reports. Vol. 3. Num. 2. 2020. p. 138.
-Di Cesare, M.; Sorić, M.; Bovet, P.; Miranda, J.J.; Bhutta, Z.; Stevens, G.A.; Laxmaiah, A.; Kengne, A.P.; Bentham, J. The Epidemiological Burden of Obesity in Childhood: A Worldwide Epidemic Requiring Urgent Action. BMC Medicine. Vol. 17. Num. 1. 2019. p. 212.
-Gamba, F.P.; Siqueira, B.S.; Tsuchiya, R.S.; Tanaka, T.M.; Grassiolli, S. O impacto do Bypass Gástrico em Y de Roux e da Gastrectomia Vertical na perda de peso: um estudo retrospectivo e longitudinal no Estado do Paraná, Brasil. Revista do Colégio Brasileiro de Cirurgiões. Vol. 50. 2023. e20233431.
-Gonçalves, M.M.P.; Iannuzzi, G.C.; Rodrigues, M.M.; Jesus-Silva, S.G. Associação entre perda de peso e redução do uso de fármacos anti-hipertensivos, hipoglicemiantes, psicotrópicos e antidislipidêmicos em pacientes submetidos a cirurgia bariátrica. HSJ. Vol. 11. Num. 1. 2021. p. 6-13.
-Inge, T.H.; Jenkins, T.M.; Xanthakos, S.A.; Dixon, J.B.; Daniels, S.R.; Zeller, M.H.; Helmrath, M.A. Long-Term Outcomes of Bariatric Surgery in Adolescents with Severe Obesity (FABS-5+): A Prospective Follow-Up Analysis. The Lancet, Diabetes & Endocrinology. Vol. 5. Num. 3. 2017. p. 165-173.
-Jammu, G.S.; Sharma, R. A 7-Year Clinical Audit of 1107 Cases Comparing Sleeve Gastrectomy, Roux-En-Y Gastric Bypass, and Mini-Gastric Bypass, to Determine an Effective and Safe Bariatric and Metabolic Procedure. Obesity Surgery. Vol. 26. Num. 5. 2016. p. 926-932.
-Järvholm, K.; Bruze, G.; Peltonen, M.; Marcus, C.; Flodmark, C.E.; Henfridsson, P.; Beamish, A.J.; Gronowitz, E.; Dahlgren, J.; Karlsson, J.; Olbers, T. 5-Year Mental Health and Eating Pattern Outcomes Following Bariatric Surgery in Adolescents: A Prospective Cohort Study. Lancet Child & Adolescents Health. Vol. 4. Num. 3. 2020. p. 210-219.
-Lamoshi, A.; Chernoguz, A.; Harmon, C.M.; Helmrath, M. Complications of Bariatric Surgery in Adolescents. Seminars in Pediatric Surgery. Vol. 29. Num. 1. 2020.
-Matheson, B.E.; Colborn, D.; Bohon, C. Bariatric Surgery in Children and Adolescents with Cognitive Impairment and/or Developmental Delay: Current Knowledge and Clinical Recommendations. Obesity Surgery. Vol. 29. Num. 12. 2019. p. 4114-4126.
-Mechanick, J.I.; Apovian, C.; Brethauer, S.; Garvey, W.T.; Joffe, A.M.; Kim, J.; Kushner, R.F.; Lindquist, R.; Pessah-Pollack, R.; Seger, J.; Urman, R.D.; Adams, S.; Cleek, J.B.; Correa, R.; Figaro, M.K.; Flanders, K.; Grams, J.; Hurley, D.L.; Kothari, S.; Seger, M.V.; Still, C.D. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures - 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, the Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists - Executive Summary. Endocrine Practice. Vol. 25. Num. 12. 2019. p. 1346-1359.
-Monasta, L.; Batty, G.D.; Cattaneo, A.; Lutje, V.; Ronfani, L.; Van Lenthe, F.J.; Brug, J. Early-Life Determinants of Overweight and Obesity: A Review of Systematic Reviews. Obesity Reviews. Vol. 11. Num. 10. 2010. p. 695-708.
-Monteforte, M.J.; Turkelson, C.M. Bariatric Surgery for Morbid Obesity. Obesity Surgery. Vol. 10. Num. 5. 2000. p. 391-401.
-Nguyen, N.T.; Varela, J.E. Bariatric Surgery for Obesity and Metabolic Disorders: State of the Art. Nature Reviews Gastroenterology & Hepatology. Vol. 14. Num. 3. 2017. p. 160-169.
-O’Kane, M.; Parretti, H.M.; Pinkney, J.; Welbourn, R.; Hughes, C.A.; Mok, J.; Walker, N.; Thomas, D.; Devin, J.; Coulman, K.D.; Pinnock, G.; Batterham, R.L.; Mahawar, K.K.; Sharma, M.; Blakemore, A.I.; McMillan, I.; Barth, J.H. British Obesity and Metabolic Surgery Society Guidelines on Perioperative and Postoperative Biochemical Monitoring and Micronutrient Replacement for Patients Undergoing Bariatric Surgery: 2020 Update. Obesity Reviews. Vol. 21. Num. 11. 2020. e13087.
-Olbers, T.; Beamish, A.J.; Gronowitz, E.; Flodmark, C.E.; Dahlgren, J.; Bruze, G.; Ekbom, K.; Friberg, P.; Göthberg, G.; Järvholm, K.; Karlsson, J.; Mårild, S.; Neovius, M.; Peltonen, M.; Marcus, C. Laparoscopic Roux-en-Y Gastric Bypass in Adolescents with Severe Obesity (AMOS): A Prospective, 5-Year, Swedish Nationwide Study. The Lancet Diabetes & Endocrinology. Vol. 5. Num. 3. 2017. p. 174-183.
-Pepe, R.B.; Lottenberg, A.M.; Fujiwara, C.T.H.; Beyruti, M.; Cintra, D.E.; Machado, R.M.; Rodrigues, A.; Jensen, N.S.O.; Caldas, A.P.S.; Fernandes, A.E.; Rossoni, C.; Mattos, F.; Motarelli, J.H.F.; Bressan, J.; Saldanha, J.; Beda, L.M.M.; Lavrador, M.S.F.; Del Bosco, M.; Cruz, P.; Correia, P.E.; Maximino, P.; Pereira, S.; Faria, S.L.; Piovacari, S.M.F. Position Statement on Nutrition Therapy for Overweight and Obesity: Nutrition Department of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso-2022). Diabetology & Metabolic Syndrome. Vol. 15. Num. 1. 2023. p. 124.
-Quek, Y.H.; Tam, W.W.S.; Zhang, M.W.B.; Ho, R.C.M. Exploring the Association Between Childhood and Adolescent Obesity and Depression: A Meta-Analysis. Obesity Reviews. Vol. 18. Num. 7. 2017. p. 742-754.
-Seva, D.C.; Mônico-Neto, M.; Antunes, H.K.M.; Pino, J.M.V.; Bittencourt, L.R.A.; Galvão, T.D.; Dâmaso, A.R.; Oyama, L.M.; Shivappa, N.; Hébert, J.R.; Tufik, S.; Campos, R.M.S. Beneficial Short-Term Effects of Bariatric Surgery on Nutritional Inflammatory Profile and Metabolic Biomarkers. Obesity Reviews. Vol. 33. Num. 9. 2023. p. 2789-2798.
-Silva, L.B.; Quadros, L.G.D.; Campos, J.M.; Boas, M.L.V.; Marchesini, J.C.; Ferraz, A.A.B.; Kaiser Junior, R.L.; Elias, A.A.; Vitor, R.; Chaves, L.C.; Ramos, A.C. Brazilian National Bariatric Registry: Pilot Study. Revista do Colégio Brasileiro de Cirurgiões. Vol. 50. 2023. e20233382.
-Van de Laar, A.W.; De Brauw, L.M.; Meesters, E.W. Relationships Between Type 2 Diabetes Remission After Gastric Bypass and Different Weight Loss Metrics: Arguments Against Excess Weight Loss in Metabolic Surgery. Surgery for Obesity & Related Diseases. Vol. 12. Num. 2. 2016. p. 274-282.
-Westling, A.; Gustavsson, S. Laparoscopic vs Open Roux-en-Y Gastric Bypass: A Prospective, Randomized Trial. Obesity Surgery. Vol. 11. Num. 3. 2001. p. 284-292.
-Wilson, J.A. Gastric Bypass in Adolescents: Should They Have Priority? The Journal of the Royal College of Physicians of Edinburgh. Vol. 49. Num. 3. 2019. p. 225-226.
-Wrobleski, M.M.; Parker, E.A.; Hager, E.; Hurley, K.M.; Oberlander, S.; Merry, B.C.; Black, M.M. Friends and Family: How African-American Adolescents’ Perceptions of Dietary Beliefs and Behaviors of Others Relate to Diet Quality. Journal of the Academy of Nutrition and Dietetics. Vol. 118. Num. 12. 2018. p. 2302-2310.
-Zeve, J.L.M.; Tomaz, C.A.B.; Nassif, P.A.N.; Lima, J.H.; Sansana, L.R.Z.; Zeve, C.H. Obesos diabéticos tipo 2 submetidos à derivação gástrica em Y-de-Roux: análise de resultados e influência nas complicações. Arquivos Brasileiros de Cirurgia Digestiva. Vol. 26. 2023. p. 47-52.
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